According to a new report commissioned by Nottingham Trent University, the institution contributed £496m to the UK economy through its staff and students for the 2014/15 academic year.
As a result of the economic contribution the University generated 9,372 jobs, both directly and indirectly.
In particular Nottingham City saw a £385m windfall, which supported 6,315 jobs. Meanwhile, the student population was directly responsible for more than £189m of the impact on the UK's economy in off-campus expenditure.
Pro Vice-Chancellor of Employer and Economic Engagement, Mike Carr, said: "This assessment shows the huge economic contribution Nottingham Trent University, our staff and student population, make to the city of Nottingham, as well as the wider region and the UK as a whole".
The assessment covered the 2014-15 academic year and reported that in total there were 26,895 students studying at Nottingham Trent University, including 2,821 students from Nottingham and a further 5,258 students from other parts of the East Midlands.
The university directly employed 3,530 staff across its campuses in the city, Clifton and Brackenhurst.
The report was released as the University prepares itself to welcome nearly 7,000 undergraduate students to its various campuses this week.